Hybrid epithelial-mesenchymal status of lung cancer dictates metastatic success through differential interaction with NK cells.

ABSTRACT:

Background

Epithelial to mesenchymal transition (EMT) endows cancer cells with pro-metastatic properties, which appear most effective when cells enter an intermediate hybrid (H) state, characterized by integrated mesenchymal (M) and epithelial (E) traits. The reasons for this advantage are poorly known and, especially, it is totally unexplored whether the interplay between H-cells and NK cells could have a role. Here we characterize the pro-metastatic mechanics of non-small cell lung cancer (NSCLC) H-cells and their subset of cancer-initiating cells (CICs), dissecting crucial interactions with NK cells.

Methods

Human lung cancer cell lines and sublines representative of E, M, or H states, assessed by proteomics, were analyzed in vivo for their tumor-forming and disseminating

SUBMITTER: Parodi M 

PROVIDER: S-EPMC10921513 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature