Timing of CHolecystectomy In Severe PAncreatitis (CHISPA): study protocol for a randomized controlled trial.

ABSTRACT: Acute pancreatitis is the recurrent reason for gastrointestinal admission in a clinical urgent setting, it happens secondary to a wide array of pathologies out of which biliary disease stands as one of the most frequent causes for its presentation. Approximately 20% of pancreatitis are of moderate or severe severity. Currently, there is not a clear recommendation on timing for cholecystectomy, either early or delayed. CHISPA is a randomized controlled, parallel-group, superior clinical trial. An intention-to-treat analysis will be performed. It seeks to evaluate differences between patients taken to early cholecystectomy during hospital admission (72 hours after randomization) versus delayed cholecystectomy (30±5 days after randomization). The primary endpoint is major complications associ

SUBMITTER: Ramirez-Giraldo C 

PROVIDER: S-EPMC10921534 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature