A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle.

ABSTRACT: Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by mounting evidence. Cancer cells heavily rely on glutamine as a critical nutrient for survival and proliferation, while immune cells require glutamine for activation and proliferation during immune reactions. This metabolic competition creates a dynamic tug-of-war between cancer and immune cells. Targeting glutamine transporters and downstream enzymes involved in glutamine metabolism holds significant promise in enhancing anti-tumor immunity. A comprehensive understanding of the intricate molecular mechanisms underlying this interplay is crucial f

SUBMITTER: Wang B 

PROVIDER: S-EPMC10921613 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature