A biodegradable PVA coating constructed on the surface of the implant for preventing bacterial colonization and biofilm formation.

ABSTRACT:

Background

Bone implant infections pose a critical challenge in orthopedic surgery, often leading to implant failure. The potential of implant coatings to deter infections by hindering biofilm formation is promising. However, a shortage of cost-effective, efficient, and clinically suitable coatings persists. Polyvinyl alcohol (PVA), a prevalent biomaterial, possesses inherent hydrophilicity, offering potential antibacterial properties.

Methods

This study investigates the PVA solution's capacity to shield implants from bacterial adhesion, suppress bacterial proliferation, and thwart biofilm development. PVA solutions at concentrations of 5%, 10%, 15%, and 20% were prepared. In vitro assessments evaluated PVA's ability to impede bacterial growth and biofilm formation. The inte

SUBMITTER: Lei Z 

PROVIDER: S-EPMC10921624 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature