Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination.

ABSTRACT:

Background

The emergence of new SARS-CoV-2 variants and the waning of immunity raise concerns about vaccine effectiveness and protection against COVID-19. While antibody response has been shown to correlate with the risk of infection with the original variant and earlier variants of concern, the effectiveness of antibody-mediated protection against Omicron and the factors associated with protection remain uncertain.

Methods

We evaluated antibody responses to SARS-CoV-2 spike (S) and nucleocapsid (N) antigens from Wuhan and variants of concern by Luminex and their role in preventing breakthrough infections 1 year after a third dose of mRNA vaccination, in a cohort of health care workers followed since the pandemic onset in Spain (N = 393). Data were analyzed in relation to CO

SUBMITTER: Martin Perez C 

PROVIDER: S-EPMC10921636 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature