Efficient and scalable gene delivery method with easily generated cationic carbon dots.

ABSTRACT: Gene delivery is a complex process with several challenges when attempting to incorporate genetic material efficiently and safely into target cells. Some of the key challenges include not only efficient cellular uptake and endosomal escape to ensure that the genetic material can exert its effect but also minimizing the toxicity of the delivery system, which is vital for safe gene delivery. Of importance, if gene delivery systems are intended for biomedical applications or clinical use, they must be scalable and easy and affordable to manufacture to meet the demand. Here, we show an efficient gene delivery method using a combination of carbon dots coated by PEI through electrostatic binding to easily generate cationic carbon dots. We show a biofunctional approach to generate optimal cationi

SUBMITTER: Algarra M 

PROVIDER: S-EPMC10921679 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature