Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients.

ABSTRACT:

Background

Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and paracrine inflammation; and obesity has been associated with premature immunosenescence, microbial translocation, and dysfunctional innate immune responses leading to poor immune response against a range of viruses and bacterial infections. Here, we have comprehensively characterized the immunosenescence, microbial translocation, and immune dysregulation established in hospitalized COVID-19 patients with different degrees of body weight.

Results

Hospitalised COVID-19 patients with overweight and obesity had similarly higher plasma LPS and sCD14 levels than contr

SUBMITTER: Madruga MP 

PROVIDER: S-EPMC10921685 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature