Biotransformation of zearalenone to non-estrogenic compounds with two novel recombinant lactonases from Gliocladium.

ABSTRACT:

Background

The mycotoxin zearalenone (ZEA) produced by toxigenic fungi is widely present in cereals and its downstream products. The danger of ZEA linked to various human health issues has attracted increasing attention. Thus, powerful ZEA-degrading or detoxifying strategies are urgently needed. Biology-based detoxification methods are specific, efficient, and environmentally friendly and do not lead to negative effects during cereal decontamination. Among these, ZEA detoxification using degrading enzymes was documented to be a promising strategy in broad research. Here, two efficient ZEA-degrading lactonases from the genus Gliocladium, ZHDR52 and ZHDP83, were identified for the first time. This work studied the degradation capacity and properties of ZEA using purified recombinant

SUBMITTER: Sun Z 

PROVIDER: S-EPMC10921726 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature