Galleria mellonella in vitro model for chromoblastomycosis shows large differences in virulence between isolates.

ABSTRACT:

Background

Chromoblastomycosis is the World Health Organization (WHO)-recognized fungal implantation disease that eventually leads to severe mutilation. Cladophialophora carrionii (C. carrionii) is one of the agents. However, the pathogenesis of C. carrionii is not fully investigated yet.

Methods

We investigated the pathogenic potential of the fungus in a Galleria mellonella (G. mellonella) larvae infection model. Six strains of C. carrionii, and three of its environmental relative C. yegresii were tested. The G. mellonella model was also applied to determine antifungal efficacy of amphotericin B, itraconazole, voriconazole, posaconazole, and terbinafine.

Results

All strains were able to infect the larvae, but virulence potentials were strain-specific and showed no co

SUBMITTER: Shi D 

PROVIDER: S-EPMC10921731 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature