Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2.

ABSTRACT:

Background

A high expression pattern of minichromosome maintenance 2 (MCM2) has been observed in various cancers. MCM2 is a protein involved in the cell cycle and plays a role in cancer growth and differentiation by binding to six members of the MCM subfamily. The MCM protein family includes MCM2 through MCM7.

Methods

MCM2 has shown high expression in both lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). We investigated the characteristics of CSCs and the regulation of the epithelial-to-mesenchymal transition (EMT) phenomenon in LCSCs and GSCs by MCM2. Additionally, we explored secreted factors regulated by MCM2.

Results

There was a significant difference in survival rates between lung cancer patients and brain cancer patients based on MCM2 expression. MCM

SUBMITTER: Kahm YJ 

PROVIDER: S-EPMC10921750 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature