Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage.

ABSTRACT:

Background

With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution and their adverse health effects have attracted global attention. MPs have been detected out in human body and both MPs and NPs showed female reproductive toxicological effects in animal models. Miscarriage (abnormal early embryo loss), accounting for 15-25% pregnant women worldwide, greatly harms human reproduction. However, the adverse effects of NPs on miscarriage have never been explored.

Results

In this study, we identified that polystyrene (PS) plastics particles were present in women villous tissues. Their levels were higher in villous tissues of unexplained recurrent miscarriage (RM) patients vs. healthy control (HC) group. Furthermore, mouse ass

SUBMITTER: Wan S 

PROVIDER: S-EPMC10921758 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature