Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway.

ABSTRACT:

Background

Mammalian enabled (MENA) protein is a member of the enabled/vasodilator stimulated phosphoprotein (Ena/VASP) protein family, which regulates cytoplasmic actin network assembly. It plays a significant role in breast cancer invasion, migration, and resistance against targeted therapy and chemotherapy. However, its role in the efficacy of endocrine therapy for the hormone receptor-positive (HR⁺) breast cancer patients is not known. This study investigated the role of MENA in the resistance against tamoxifen therapy in patients with HR⁺ breast cancer and the underlying mechanisms.

Methods

MENA expression levels in the clinical HR⁺ breast cancer samples (n = 119) were estimated using immunohistochemistry (IHC) to determine its associati

SUBMITTER: He L 

PROVIDER: S-EPMC10921784 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature