Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells.

ABSTRACT:

Background

Increased mitochondrial activities contributing to cancer cell proliferation, invasion, and metastasis have been reported in different cancers; however, studies on the therapeutic targeting of mitochondria in regulating cell proliferation and invasiveness are limited. Because mitochondria are believed to have evolved through bacterial invasion in mammalian cells, antibiotics could provide an alternative approach to target mitochondria, especially in cancers with increased mitochondrial activities. In this study, we investigated the therapeutic potential of bacteriostatic antibiotics in regulating the growth potential of colorectal cancer (CRC) cells, which differ in their metastatic potential and mitochondrial functions.

Methods

A combination of viability, cell mi

SUBMITTER: Mathur S 

PROVIDER: S-EPMC10921801 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature