Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer.

ABSTRACT:

Background

The histological grade is an important factor in the prognosis of invasive breast cancer and is vital to accurately identify the histological grade and reclassify of Grade2 status in breast cancer patients.

Methods

In this study, data were collected from 556 invasive breast cancer patients, and then randomly divided into training cohort (n = 335) and validation cohort (n = 221). All patients were divided into actual low risk group (Grade1) and high risk group (Grade2/3) based on traditional histological grade, and tumor-infiltrating lymphocyte score (TILs-score) obtained from multiphoton images, and the TILs assessment method proposed by International Immuno-Oncology Biomarker Working Group (TILs-WG) were also used to differentiate between high risk group and low

SUBMITTER: Kang D 

PROVIDER: S-EPMC10921807 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature