Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy.

ABSTRACT:

Background

The World Health Organization recommends 1500 to 2000 mg of calcium daily as supplementation, divided into three doses, for pregnant persons in populations with low dietary calcium intake in order to reduce the risk of preeclampsia. The complexity of the dosing scheme, however, has led to implementation barriers.

Methods

We conducted two independent randomized trials of calcium supplementation, in India and Tanzania, to assess the noninferiority of a 500-mg daily dose to a 1500-mg daily dose of calcium supplementation. In each trial, the two primary outcomes were preeclampsia and preterm birth, and the noninferiority margins for the relative risks were 1.54 and 1.16, respectively.

Results

A total of 11,000 nulliparous pregnant women were included in each tr

SUBMITTER: Dwarkanath P 

PROVIDER: S-EPMC10921922 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature