Identification and validation of shared gene signature of kidney renal clear cell carcinoma and COVID-19.

ABSTRACT:

Background

COVID-19 is a severe infectious disease caused by the SARS-CoV-2 virus, and previous studies have shown that patients with kidney renal clear cell carcinoma (KIRC) are more susceptible to SARS-CoV-2 infection than the general population. Nevertheless, their co-pathogenesis remains incompletely elucidated.

Methods

We obtained shared genes between these two diseases based on public datasets, constructed a prognostic risk model consisting of hub genes, and validated the accuracy of the model using internal and external validation sets. We further analyzed the immune landscape of the prognostic risk model, investigated the biological functions of the hub genes, and detected their expression in renal cell carcinoma cells using qPCR. Finally, we searched the candidate d

SUBMITTER: Nie J 

PROVIDER: S-EPMC10921934 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature