Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain.

ABSTRACT:

Abstract

Decades of efforts in elucidating pain mechanisms, including pharmacological, neuroanatomical, and physiological studies have provided insights into how nociceptive information transmits from the periphery to the brain and the locations receiving nociceptive signals. However, little is known about which specific stimulus-dependent activated neurons, amongst heterogeneous neural environments, discriminatively evoke the cognate pain behavior. We here shed light on the population of neurons in the spinal cord activated by a painful stimulus to identify chronic pain-dependent activated neuronal subsets using Fos2A-iCreER (TRAP2) mice. We have found a large number of neurons activated by a normally nonpainful stimulus in the spinal cord of spinal nerve-ligated mice, compared wi

SUBMITTER: Targowska-Duda KM 

PROVIDER: S-EPMC10922047 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature