The intestinal microbiome of children with initial and recurrent nephrolithiasis: A pilot study and exploratory analysis.

ABSTRACT:

Introduction

Kidney stone disease in children is rising disproportionate to the general population, representing a disease population with a distinct biological mechanism as compared to adults. Factors influencing recurrent kidney stone disease in children are poorly characterized and the associations of the intestinal microbiome within sub-populations of kidney stone formers, however, are not well described. We evaluated a pilot cohort of children with nephrolithiasis comparing patients based on recurrent kidney stone episodes and abnormal 24-h urinary parameters, with dual aims to compare the microbiome signal in children with initial and recurrent nephrolithiasis and to explore additional associations in microbiome composition and diversity within this population.

Methods

SUBMITTER: Ellison JS 

PROVIDER: S-EPMC10922064 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature