Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals.

ABSTRACT:

Objective

Biomarkers of Alzheimer disease vary between groups of self-identified Black and White individuals in some studies. This study examined whether the relationships between biomarkers or between biomarkers and cognitive measures varied by racialized groups.

Methods

Cerebrospinal fluid (CSF), amyloid positron emission tomography (PET), and magnetic resonance imaging measures were harmonized across four studies of memory and aging. Spearman correlations between biomarkers and between biomarkers and cognitive measures were calculated within each racialized group, then compared between groups by standard normal tests after Fisher's Z-transformations.

Results

The harmonized dataset included at least one biomarker measurement from 495 Black and 2,600 White participan

SUBMITTER: Bonomi S 

PROVIDER: S-EPMC10922199 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature