Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder.

ABSTRACT:

Background

Alcohol use disorder (AUD) is associated with increased mortality and morbidity risk. A reason for this could be accelerated biological aging, which is strongly influenced by disease processes such as inflammation. As recent studies of AUD show changes in DNA methylation and gene expression in neuroinflammation-related pathways in the brain, biological aging represents a potentially important construct for understanding the adverse effects of substance use disorders. Epigenetic clocks have shown accelerated aging in blood samples from individuals with AUD. However, no systematic evaluation of biological age measures in AUD across different tissues and brain regions has been undertaken.

Methods

As markers of biological aging (BioAge markers), we assessed Levine's a

SUBMITTER: Zillich L 

PROVIDER: S-EPMC10922212 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature