Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States.

ABSTRACT:

Objective

Recent studies have uncovered diverse cell types and states in the rheumatoid arthritis (RA) synovium; however, limited data exist correlating these findings with patient-level clinical information. Using the largest cohort to date with clinical and multicell data, we determined associations between RA clinical factors with cell types and states in the RA synovium.

Methods

The Accelerated Medicines Partnership Rheumatoid Arthritis study recruited patients with active RA who were not receiving disease-modifying antirheumatic drugs (DMARDs) or who had an inadequate response to methotrexate (MTX) or tumor necrosis factor inhibitors. RA clinical factors were systematically collected. Biopsies were performed on an inflamed joint, and tissue were disaggregated and proces

SUBMITTER: Weisenfeld D 

PROVIDER: S-EPMC10922423 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature