Paired DBS and TMS Reveals Dentato-Cortical Facilitation Underlying Upper Extremity Movement in Chronic Stroke Survivors.

ABSTRACT:

Background

Cerebellum shares robust di-synaptic dentato-thalamo-cortical (DTC) connections with the contralateral motor cortex. Preclinical studies have shown that DTC are excitatory in nature. Structural integrity of DTC is associated with better upper extremity (UE) motor function in people with stroke, indicating DTC are important for cerebellar influences on movement. However, there is a lack of understanding of physiologic influence of DTC in humans, largely due to difficulty in accessing the dentate nucleus.

Objective

Characterize DTC physiology using dentate nucleus deep brain stimulation (DBS) combined with transcranial magnetic stimulation (TMS) in stroke.

Methods

Nine chronic stroke survivors with moderate-to-severe UE impairment (Fugl-Meyer 13-38) underwent

SUBMITTER: Li X 

PROVIDER: S-EPMC10922453 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature