Coagulation factor XIII is a critical driver of liver regeneration after partial hepatectomy.

ABSTRACT:

Background

Activation of coagulation and fibrin deposition in the regenerating liver appears to promote adequate liver regeneration in mice. In humans, perioperative hepatic fibrin deposition is reduced in patients who develop liver dysfunction after partial hepatectomy (PHx), but the mechanism underlying reduced fibrin deposition in these patients is unclear.

Methods and results

Hepatic deposition of cross-linked (ie, stabilized) fibrin was evident in livers of mice after two-thirds PHx. Interestingly, hepatic fibrin cross-linking was dramatically reduced in mice after 90% PHx, an experimental setting of failed liver regeneration, despite similar activation of coagulation after two-thirds or 90% PHx. Likewise, intraoperative activation of coagulation was not reduced in pati

SUBMITTER: Wei Z 

PROVIDER: S-EPMC10922479 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature