Causal Factors for Osteoarthritis: A Scoping Review of Mendelian Randomization Studies.

ABSTRACT:

Objective

Mendelian randomization (MR) has increasingly been utilized as a tool for establishing causal relations between modifiable exposures and osteoarthritis (OA). The goal of this review was to summarize available MR studies of OA that evaluate the causal role of modifiable risk factors on OA.

Methods

This review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Extension for Scoping Reviews model. We performed a literature search for relevant studies published before December 2021 across multiple databases using the search terms "osteoarthritis" and ("Mendelian randomization" or "polygenic risk score"). We reported the MR estimates of causal associations between exposures and OA and then assessed methodologic qualit

SUBMITTER: Alhassan E 

PROVIDER: S-EPMC10922494 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature