Optimizing the sodium iodate model: Effects of dose, gender, and age.

ABSTRACT: Sodium iodate (NaIO₃) is a commonly used model for age-related macular degeneration (AMD), but its rapid and severe induction of retinal pigment epithelial (RPE) and photoreceptor degeneration can lead to the premature dismissal of potentially effective therapeutics. Additionally, little is known about how sex and age affect the retinal response to NaIO₃. This study aims to establish a less severe yet reproducible regimen by testing low doses of NaIO₃ while considering age- and sex-related effects, enabling a broader range of therapeutic evaluations. In this study, young (3-5 months) and old (18-24 months) male and female C57Bl/6J mice were given an intraperitoneal (IP) injection of 15, 20, or 25 mg/kg NaIO₃. Damage assessment one week post-injec

SUBMITTER: Anderson BD 

PROVIDER: S-EPMC10922497 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature