P2X7-Mediated Antigen-Independent Activation of CD8⁺ T Cells Promotes Salt-Sensitive Hypertension.

ABSTRACT:

Background

CD8⁺ T cells (CD8Ts) have been implicated in hypertension. However, the specific mechanisms are not fully understood. In this study, we explore the contribution of the P2X7 (purinergic receptor P2X7) receptor to CD8T activation and subsequent promotion of sodium retention in the kidney.

Methods

We used mouse models of hypertension. Wild type were used as genetic controls, OT1 and Rag2/OT1 mice were utilized to determine antigen dependency, and P2X7-knockout mice were studied to define the role of P2X7 in activating CD8Ts and promoting hypertension. Blood pressure was monitored continuously and kidneys were obtained at different experimental end points. Freshly isolated CD8Ts from mice for activation assays and ATP stimulation. CD8T activation-induced pr

SUBMITTER: Benson LN 

PROVIDER: S-EPMC10922507 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature