Phthalate exposure increases interferon-γ during pregnancy: The Atlanta African American Maternal-Child Cohort.

ABSTRACT:

Background

The immune system undergoes unique adaptations during pregnancy and is particularly sensitive to environmental chemicals, such as phthalates, which are associated with acute and chronic inflammatory medical conditions. However, current knowledge of how phthalate exposures are associated with systemic inflammation in pregnant people is limited by cross-sectional study designs and single chemical models. Our objective was to estimate the association between repeated measures of prenatal phthalate exposures, examined individually and collectively, and a panel of clinical inflammatory biomarkers.

Methods

In the Atlanta African American Maternal-Child Cohort, biospecimens were collected at mean 11 and 26 weeks gestation (N = 126). Concentrations of eight urinary phthal

SUBMITTER: Taibl KR 

PROVIDER: S-EPMC10922519 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature