Fetal growth assessed via ultrasound in relation to maternal HIV infection status and antiretroviral regimens.

ABSTRACT:

Objective

To evaluate effects of maternal HIV and antiretroviral treatment (ART) on intrauterine fetal growth.

Design

Prospective cohort studies of HIV and ZIKA infection among women living with HIV (WLHIV) and women not living with HIV (WNLHIV) conducted in Brazil and the US from 2016 to 2020.

Methods

We evaluated fetal growth via repeated ultrasounds and calculated z scores for fetal growth measures using Intergrowth-21st standards among women with singleton pregnancies. Adjusted linear mixed models were fit for each fetal growth z score by HIV status. Among WLHIV, we compared fetal growth z scores by the most common maternal ART regimens, stratified by timing of ART initiation.

Results

We included 166 WLHIV and 705 WNLHIV; none had Zika infection. The z scor

SUBMITTER: Williams PL 

PROVIDER: S-EPMC10922527 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature