Tumor-Specific Activity of Precision Medicines in the NCI-MATCH Trial.

ABSTRACT:

Purpose

National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH) is a precision medicine basket trial designed to test the effectiveness of treating cancers based on specific genetic changes in patients' tumors, regardless of cancer type. Multiple subprotocols have each tested different targeted therapies matched to specific genetic aberrations. Most subprotocols exhibited low rates of tumor shrinkage as evaluated across all tumor types enrolled. We hypothesized that these results may arise because these precision cancer therapies have tumor type-specific efficacy, as is common among other cancer therapies.

Experimental design

To test the hypothesis that certain tumor types are more sensitive to specific therapies than other tumor types, we applied permuta

SUBMITTER: Zhou I 

PROVIDER: S-EPMC10922532 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature