Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.

ABSTRACT:

Background

The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.

Methods

We analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (n=35 660) and UK Biobank (n=91 622) and performed European population-specific and cross-population meta-analyses.

Results

We identified 3 loci in European-specific analyses and an additional 4 loci in cross-population analyses at P_interaction<5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele fr

SUBMITTER: Guirette M 

PROVIDER: S-EPMC10922535 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature