Alliance A151945: Accrual and characteristics of adolescent and young adult patients in Alliance trials from 2000 to 2017.

ABSTRACT:

Background

Identifying patient- and disease-specific characteristics associated with clinical trial enrollment of adolescents and young adults (AYAs) with cancer may target efforts to improve accrual.

Methods

Alliance for Clinical Trials in Oncology (Alliance) trials opened from January 1, 2000, and closed before January 1, 2018, for common AYA cancers were identified. Proportions of AYAs (aged 18-39 years old) versus non-AYAs (aged ≥40 years old) enrolled by cancer type were summarized by descriptive statistics. Among studies with ≥20 AYAs enrolled, demographic and disease characteristics of AYAs versus non-AYAs were compared with χ² and Kruskal-Wallis tests. A qualitative review was also conducted of therapeutic trials included in analysis in PubMed through Dece

SUBMITTER: Rosenberg SM 

PROVIDER: S-EPMC10922614 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature