Prenatal arsenite exposure alters maternal cardiac remodeling during late pregnancy.

ABSTRACT: Exposure to inorganic arsenic through drinking water is widespread and has been linked to many chronic diseases, including cardiovascular disease. Arsenic exposure has been shown to alter hypertrophic signaling in the adult heart, as well as in utero offspring development. However, the effect of arsenic on maternal cardiac remodeling during pregnancy has not been studied. As such, there is a need to understand how environmental exposure contributes to adverse pregnancy-related cardiovascular events. This study seeks to understand the impact of trivalent inorganic arsenic exposure during gestation on maternal cardiac remodeling in late pregnancy, as well as offspring outcomes. C57BL/6 J mice were exposed to 0 (control), 100 or 1000 μg/L sodium arsenite (NaAsO₂) beginning at embry

SUBMITTER: Taube N 

PROVIDER: S-EPMC10922692 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature