Frequency of Comorbid Pathologies and Their Clinical Impact in Multiple System Atrophy.

ABSTRACT:

Background

Mixed pathology is common at autopsy for a number of age-associated neurodegenerative disorders; however, the frequency of comorbid pathologies in multiple system atrophy (MSA) and their clinical correlations are poorly understood.

Objective

We determined the frequency of comorbid pathologic processes in autopsy-confirmed MSA and assessed their clinical correlates.

Methods

This study included 160 neuropathologically established MSA from the Mayo Clinic brain bank. Clinical information, including age at onset or death, clinical subtype, initial symptoms, antemortem clinical diagnosis, and cognitive dysfunction was collected. We assessed comorbid pathologies including Alzheimer's disease neuropathologic change, Lewy-related pathology, argyrophilic grain disea

SUBMITTER: Sekiya H 

PROVIDER: S-EPMC10922743 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature