Proteomic Analyses of Plasma From Patients With Fracture-Related Infection Reveals Systemic Activation of the Complement and Coagulation Cascades.

ABSTRACT:

Objectives

The objective of this study was to compare plasma proteomes of patients with confirmed fracture-related infections (FRIs) matched to noninfected controls using liquid chromatography-mass spectrometry.

Methods

Design

This was a prospective case-control study.

Setting

The study was conducted at a single, academic, Level 1 trauma center.

Patient selection criteria

Patients meeting confirmatory FRI criteria were matched to controls without infection based on fracture region, age, and time after surgery from June 2019 to January 2022. Tandem mass tag liquid chromatography-mass spectrometry analysis of patient plasma samples was performed.

Outcome measures and comparisons

Protein abundance ratios in plasma for patients with FRI compared with

SUBMITTER: Becker K 

PROVIDER: S-EPMC10922838 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature