Cerebral vascular and blood brain-barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex.

ABSTRACT:

Objective

Tuberous sclerosis complex (TSC) is a genetic disorder, characterized by tumor formation in the brain and other organs, and severe neurological symptoms, such as epilepsy. Abnormal vascular endothelial growth factor (VEGF) expression may promote angiogenesis in kidney and lung tumors in TSC and has been identified in brain specimens from TSC patients, but the role of VEGF and vascular abnormalities in neurological manifestations of TSC is poorly defined. In this study, we investigated abnormalities in brain VEGF expression, cerebral blood vessel anatomy, and blood-brain barrier (BBB) structure and function in a mouse model of TSC.

Methods

Tsc1^GFAP CKO mice were used to investigate VEGF expression and vascular abnormalities in the brain by Western blottin

SUBMITTER: Guo D 

PROVIDER: S-EPMC10922951 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature