Human In vitro Modeling Identifies Adjuvant Combinations that Unlock Antigen Cross-presentation and Promote T-helper 1 Development in Newborns, Adults and Elders.

ABSTRACT: Adjuvants are vaccine components that can boost the type, magnitude, breadth, and durability of an immune response. We have previously demonstrated that certain adjuvant combinations can act synergistically to enhance and shape immunogenicity including promotion of Th1 and cytotoxic T-cell development. These combinations also promoted protective immunity in vulnerable populations such as newborns. In this study, we employed combined antigen-specific human in vitro models to identify adjuvant combinations that could synergistically promote the expansion of vaccine-specific CD4⁺ cells, induce cross-presentation on MHC class I, resulting in antigen-specific activation of CD8⁺ cells, and direct the balance of immune response to favor the production of Th1-promoting cytoki

SUBMITTER: Thomas S 

PROVIDER: S-EPMC10922990 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature