Decreasing polypharmacy in older adults with cancer: A pilot cluster-randomized trial protocol.

ABSTRACT:

Introduction

Polypharmacy is prevalent in older adults with cancer and associated with multiple adverse outcomes. A single-site, cluster-randomized clinical trial will enroll older adults with cancer and polypharmacy starting chemotherapy and will assess the effectiveness and feasibility of deprescribing interventions by comparing two arms: a pharmacist-led deprescribing intervention and a patient educational brochure.

Materials and methods

The study will be conducted in two phases. In phase I, focus groups and semi-structured individual interviews will guide adaptation of deprescribing interventions for the oncology clinic (phase Ia), and eight patients will undergo the pharmacist-led deprescribing intervention with iterative adaptations (phase Ib). In phase II, a pilot clu

SUBMITTER: Ramsdale E 

PROVIDER: S-EPMC10923001 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature