Pivotal role of myeloid-derived suppressor cells in infection-related tumor growth.

ABSTRACT:

Background

In this study, we investigated infection-related tumor growth, focusing on myeloid-derived suppressor cells (MDSCs) in clinical and experimental settings.

Patients and methods

In the clinical study, a total 109 patients who underwent gastrectomy or esophagectomy were included. Blood samples were collected from a preoperative time point through 3 months after surgery, and MDSCs were analyzed using flow cytometry. In animal experiments, peritonitis model mice were created by CLP method. We investigated the number of splenic MDSCs in these mice using flow cytometry. Malignant melanoma cells (B16F10) were inoculated on the back of the mice, and tumor growth was monitored. We compared the level of MDSC infiltration around the tumor and the migration ability between CLP

SUBMITTER: Ito N 

PROVIDER: S-EPMC10923041 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature