A biomechanical assessment of tissue-engineered polymer neo-uteri after orthotopic implantation.

ABSTRACT:

Objective

To assess the in vivo biomechanical maturation of tissue-engineered neo-uteri that have previously supported live births in a rabbit model.

Design

Nonclinical animal study.

Setting

University-based research laboratory.

Animals

Eighteen adult female rabbits.

Intervention

Biodegradable poly-DL-lactide-co-glycolide-coated polyglycolic acid scaffolds seeded with autologous uterine-derived endometrial and myometrial cells. Nonseeded scaffolds and seeded, tissue-engineered neo-uteri were implanted into one uterine horn of rabbits for 1, 3, or 6 months, excised, and biomechanically assessed in comparison to native uterine tissue.

Main outcome measures

Tensile stress-relaxation testing, strain-to-failure testing, and viscoelastic modeling.

Re

SUBMITTER: Nordberg RC 

PROVIDER: S-EPMC10923056 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature