Transcription-replication interactions reveal bacterial genome regulation.

ABSTRACT: Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome¹. In bacteria, the relationship between the regulatory architecture of a gene and its expression is well understood for individual model gene circuits^2,3. However, a broader perspective of these dynamics at the genome scale is lacking, in part because bacterial transcriptomics has hitherto captured only a static snapshot of expression averaged across millions of cells⁴. As a result, the full diversity of gene expression dynamics and their relation to regulatory architecture remains unknown. Here we present a novel genome-wide classification of regulatory modes based on the transcriptional response of each gene to its own replicati

SUBMITTER: Pountain AW 

PROVIDER: S-EPMC10923101 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature