Complement C1q essential for aeroallergen sensitization via CSF1R⁺ conventional dendritic cells type 2.

ABSTRACT:

Background

Dendritic cells (DCs) are heterogeneous, comprising multiple subsets with unique functional specifications. Our previous work has demonstrated that the specific conventional type 2 DC subset, CSF1R⁺cDC2s, plays a critical role in sensing aeroallergens.

Objective

It remains to be understood how CSF1R⁺cDC2s recognize inhaled allergens. We sought to elucidate the transcriptomic programs and receptor-ligand interactions essential for function of this subset in allergen sensitization.

Methods

We applied single-cell RNA sequencing to mouse lung DCs. Conventional DC-selective knockout mouse models were employed, and mice were subjected to inhaled allergen sensitization with multiple readouts of asthma pathology. Under the clinical arm of this

SUBMITTER: Moon HG 

PROVIDER: S-EPMC10923196 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature