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Oligodendroglioma with Neuronal Differentiation in Two Boxer Dogs.

ABSTRACT: Two cases of high-grade glioma comprising sheets of oligodendroglial cells multifocally disrupted by regions of remarkable neuronal differentiation are described. These tumours morphologically resemble 'oligodendroglioma with ganglioglioma-like maturation', a rare tumour of man, but appear to be phenotypically more aggressive. Neuronal markers (synaptophysin, neuron-specific enolase and βIII-tubulin) effectively highlight neuronal elements within these tumours and could potentially help to further investigate the prevalence and biological significance of neuronal differentiation in canine oligodendroglioma.

SUBMITTER: Cornax I

PROVIDER: S-EPMC10923238 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Oligodendroglioma with Neuronal Differentiation in Two Boxer Dogs.

Cornax I I Pluhar G E GE Clark H B HB O'Sullivan M G MG

Journal of comparative pathology 20190918

Two cases of high-grade glioma comprising sheets of oligodendroglial cells multifocally disrupted by regions of remarkable neuronal differentiation are described. These tumours morphologically resemble 'oligodendroglioma with ganglioglioma-like maturation', a rare tumour of man, but appear to be phenotypically more aggressive. Neuronal markers (synaptophysin, neuron-specific enolase and βIII-tubulin) effectively highlight neuronal elements within these tumours and could potentially help to furth ...[more]

PMID: 31690408

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