Plugging the leaks: antibiotic resistance at human-animal interfaces in low-resource settings.

ABSTRACT: Antibiotic resistance is one of the greatest public health challenges of our time. International efforts to curb resistance have largely focused on drug development and limiting unnecessary antibiotic use. However, in areas where water, sanitation, and hygiene infrastructure is lacking, we propose that bacterial flow between humans and animals can exacerbate the emergence and spread of resistant pathogens. Here, we describe the consequences of poor environmental controls by comparing mobile resistance elements among Escherichia coli recovered from humans and meat in Cambodia, a middle-income country with substantial human-animal connectivity and unregulated antibiotic use. We identified identical mobile resistance elements and a conserved transposon region that were widely dispersed

SUBMITTER: Nadimpalli ML 

PROVIDER: S-EPMC10923528 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature