Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A.

ABSTRACT:

Background

The synaptic hypothesis is an influential theory of the pathoetiology of schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the synaptic terminal density marker [¹¹C]UCB-J in patients with chronic SCZ than in control participants. However, it is unclear whether these differences are present early in the illness. To address this, we investigated [¹¹C]UCB-J volume of distribution (V_T) in antipsychotic-naïve/free patients with SCZ who were recruited from first-episode services compared with healthy volunteers.

Methods

Forty-two volunteers (SCZ n = 21, healthy volunteers n = 21) underwent [¹¹C]UCB-J positron emission tomography to index [¹¹C]UCB-J V_T and distribution vo

SUBMITTER: Onwordi EC 

PROVIDER: S-EPMC10923626 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature