Proteomic analysis of serum extracellular vesicles from biliary tract infection patients to identify novel biomarkers.

ABSTRACT: Biliary tract infection (BTI), a commonly occurring abdominal disease, despite being extensively studied for its initiation and underlying mechanisms, continues to pose a challenge in the quest for identifying specific diagnostic biomarkers. Extracellular vesicles (EVs), which emanate from diverse cell types, serve as minute biological entities that mirror unique physiological or pathological conditions. Despite their potential, there has been a relatively restricted exploration of EV-oriented methodologies for diagnosing BTI. To uncover potent protein biomarkers for BTI patients, we applied a label-free quantitative proteomic method known for its unbiased and high-throughput nature. Furthermore, 192 differentially expressed proteins surfaced within EVs isolated from individuals afflicted

SUBMITTER: Chang CJ 

PROVIDER: S-EPMC10923810 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature