Immune response induced by standard and fractional doses of 17DD yellow fever vaccine.

ABSTRACT: The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization approved the use of the fractional dose (FD) of the YF vaccine due to stock shortage. In an observational cross-sectional investigation, we have assessed viremia, antibodies, soluble mediators and effector and memory T and B-cells induced by primary vaccination of volunteers with FD and standard dose (SD). Similar viremia and levels of antibodies and soluble markers were induced early after immunization. However, a faster decrease in the latter was observed after SD. The FD led to a sustained expansion of helper T-cells and an increased expression of activation markers on T-cells early after vaccination. Although with different kinetics, expansion of plasma cells was induc

SUBMITTER: Abdala-Torres T 

PROVIDER: S-EPMC10923915 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature