A proof-of-principle for decontamination of transplantation kidney through UV-C exposition of the perfusate solution.

ABSTRACT: Kidney transplantation is a common yet highly demanding medical procedure worldwide, enhancing the quality of life for patients with chronic kidney disease. Despite its prevalence, the procedure faces a shortage of available organs, partly due to contamination by microorganisms, leading to significant organ disposal. This study proposes utilizing photonic techniques associated with organ support machines to prevent patient contamination during kidney transplantation. We implemented a decontamination system using ultraviolet-C (UV-C) irradiation on the preservation solution circulating through pigs' kidneys between harvest and implant. UV-C irradiation, alone or combined with ultrasound (US) and Ps80 detergent during ex-vivo swine organ perfusion in a Lifeport® Kidney Transporter machine, a

SUBMITTER: Goenaga-Mafud LC 

PROVIDER: S-EPMC10923919 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature