The cytosolic DNA-sensing cGAS-STING pathway in neurodegenerative diseases.

ABSTRACT:

Background

With the widespread prevalence of neurodegenerative diseases (NDs) and high rates of mortality and disability, it is imminent to find accurate targets for intervention. There is growing evidence that neuroimmunity is pivotal in the pathology of NDs and that interventions targeting neuroimmunity hold great promise. Exogenous or dislocated nucleic acids activate the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS), activating the stimulator of interferon genes (STING). The activated STING triggers innate immune responses and then the cGAS-STING signaling pathway links abnormal nucleic acid sensing to the immune response. Recently, numerous studies have shown that neuroinflammation regulated by cGAS-STING signaling plays an essential role in NDs.

Aims

In this revi

SUBMITTER: Guo X 

PROVIDER: S-EPMC10924111 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature