Amantadine for functional improvement in patients with traumatic brain injury: A systematic review with meta-analysis and trial sequential analysis.

ABSTRACT:

Introduction

TBIs contribute in over one-third of injury-related deaths with mortality rates as high as 50% in trauma centers serving the most severe TBI. The effect of TBI on mortality is about 10% across all ages. Amantadine hydrochloride is one of the most commonly prescribed medications for patients undergoing inpatient neurorehabilitation who have disorders of consciousness.⁶ It is a dopamine (DA) receptor agonist and a N-Methyl-D-aspartate (NMDA) receptor antagonist via dopamine release and dopamine reuptake inhibition. The current study will synthesize the current available evidence and show the effect of Amantadine in functional improvement after TBI.

Research question

Does Amantadine have an effect on functional improvement of TBI patients?

Material an

SUBMITTER: Siy HFC 

PROVIDER: S-EPMC10924175 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature