An image-driven micromechanical approach to characterize multiscale remodeling in infarcted myocardium.

ABSTRACT: Myocardial infarction (MI) is accompanied by the formation of a fibrotic scar in the left ventricle (LV) and initiates significant alterations in the architecture and constituents of the LV free wall (LVFW). Previous studies have shown that LV adaptation is highly individual, indicating that the identification of remodeling mechanisms post-MI demands a fully subject-specific approach that can integrate a host of structural alterations at the fiber-level to changes in bulk biomechanical adaptation at the tissue-level. We present an image-driven micromechanical approach to characterize remodeling, assimilating new biaxial mechanical data, histological studies, and digital image correlation data within an in-silico framework to elucidate the fiber-level remodeling mechanisms that drive tissue

SUBMITTER: Mendiola EA 

PROVIDER: S-EPMC10924194 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature